Field updates
A curated, non-exhaustive view of 2025 breakthroughs closest to Dr. Memari's research lines — surgical oncology, non-coding RNAs and immunotherapy, and digital / AI-assisted detection.
Phase-2 data for mRNA-4157 with pembrolizumab showed a ~44% reduction in melanoma recurrence, and a pancreatic-cancer trial at Memorial Sloan Kettering with BioNTech reported vaccine-induced T-cell responses persisting for nearly four years after treatment.
A phase-1 inhibitor targeting KRAS-G12D produced substantial tumor shrinkage in roughly 61% of early non-small-cell lung-cancer patients — the first drug against a mutation long considered undruggable. Pan-KRAS compounds and PROTAC degraders are advancing in parallel for pancreatic cancer.
CLDN18.2-directed CAR-T cells demonstrated survival benefits in advanced gastric and gastroesophageal-junction cancers — the first clear solid-tumor CAR-T win — while off-the-shelf allogeneic CAR-T platforms continued progressing through phase 1/2 trials.
A cell-free-RNA assay combined with AI classifiers detected colorectal, lung, prostate, pancreatic, and breast cancers across 1,000+ patient samples with a 92% AUC and 80% sensitivity for stage-I disease — moving multi-cancer early detection (MCED) blood tests closer to primary-care use.
A University of Minnesota team reported that CRISPR-edited tumor-infiltrating lymphocytes cleared metastatic disease in a patient with advanced gastrointestinal cancer — an early but striking demonstration of gene-edited adoptive cell therapy in solid tumors.
Summaries from AACR, ASCO, and peer-reviewed coverage. Individual trial results do not constitute medical advice.
Live from PubMed
Recently indexed papers in oncology, immunotherapy, and clinical trials — fetched directly from PubMed and refreshed every couple of hours.
British journal of cancer
Zhuo G et al. · 2026 Apr 16
Read on PubMedClinical and translational allergy
Alder J et al. · 2026 Apr
Read on PubMedCancer medicine
Zhang Q et al. · 2026 Apr
Read on PubMedNature cancer
Gfeller D et al. · 2026 Apr 16
Read on PubMedNature reviews. Cancer
Schneider SM et al. · 2026 Apr 16
Read on PubMedExperimental & molecular medicine
Kim S et al. · 2026 Apr 16
Read on PubMedSource: PubMed